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Bacteriocins of class IIa, like divercin V41, are small peptide secreted by some lactic acid bacteria and show anti-listeria activity. Last decade, these bacteriocins are studied for develop new system of bio preservation and therapeutic use but matter is apparition of resistant pathogenic strains like Listeria monocytogenes and Enterococcus faecalis. Studies have showed that inactivation of rpoN gene, rpoN associate activator and mpt operon lead to resistance mechanisms in these pathogenic strains. In this work, we identified two new genes, pde and glpQ, their inactivation involved resistance of E. faecalis toward divercin V41. Resistance observed for glpQ inactivation is collaborating with bacterial membrane modification and for this observed for pde inactivation mechanisms are not elucidated. These news targets seem to be E. faecalis specific because genes are not involved in resistance of L. monocytogenes.